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Tours (France)

31 Mar
02 Apr 2020

Innate immunity in a biomineralized context: trade-offs or synergies?

This conference aims to bring together scientists working with diverse models of biomineralization, on the innate immune function of the calcified barrier. It is organized by Le Studium agency, in collaboration with Avian Biology & Poultry joint research unit (BOA), Centre INRA Val de Loire, University of Tours.

By S. Réhault-Godbert & Communication Inra Val de Loire
Updated on 10/11/2019
Published on 10/11/2019

Biomineralized structures can function as a barrier to the external environment, and as such are conceptually entwined with innate immune processes. Disentangling immune and biomineralization mechanisms represents a significant challenge for researchers trying to understand how organisms could integrate biomineral formation and plasticity with maintenance of critical innate immune protection. In fact, there is increasing evidence that immune proteins can serve genuine dual-functional roles, both in regulation of biomineralization, as well as resisting pathogens. This awareness is growing in models as diverse as the dual-functionning haemocytes of marine bivalves, and in mineralization / demineralization of the avian eggshell. Moreover, reef corals, in which calcification is coupled to the photosynthetic activity of their mutualistic symbiots, must adapt their innate immune system to achieve this tolerance. Cnidarian immune-related processes in response to abiotic stresses are increasingly implicated in loss of symbiosis and coral bleaching.

This conference aims to bring together scientists working with diverse models of biomineralization, for an exchange of perspectives on the innate immune function of the calcified barrier and the dual role played by specific genes / proteins in these two critical functions.

Convenors

  • Prof. Maxwell Hincke, LE STUDIUM Research ProfessorFROM: Innovation in Medical Education & Cellular and Molecular Medicine, University of Ottawa - CA
    IN RESIDENCE AT: Avian Biology & Poultry Research (BOA) / Centre INRA Val de Loire, University of Tours - FR
  • Dr Sophie Réhault-Godbert,
    Avian Biology & Poultry Research (BOA) / Centre INRA Val de Loire, University of Tours - FR

Location : Hôtel de Ville - Boulevard Heurteloup - 37000 TOURS - France

Contact(s)
Scientific contact(s):

Associated Division(s):
Animal Physiology and Livestock Systems , Animal Genetics
Associated Centre(s):
Val de Loire

More information

  • Presentation of the conference
     
  • Reference:
    Hincke MT, Da Silva M, Guyot N, Gautron J, McKee MD, Guabiraba-Brito R, Réhault-Godbert S.
    Dynamics of Structural Barriers and Innate Immune Components during Incubation of the Avian Egg: Critical Interplay between Autonomous Embryonic Development and Maternal Anticipation. J Innate Immun. 2019;11(2):111-124. doi: 10.1159/000493719. Epub 2018 Nov 2. Review.
    https://www.karger.com/Article/Pdf/493719